It can be done, but personally I love 6AN8s. It is half pentode half triode vs dual triode like a 12A_7 so it would be a significant mod.
There are no drop-in substitutes, but there are workalikes: 7258 (same pinout but diff heater current 13.5V vs 6.3 so nonstarter I'd think) and the 6AV8 (diff pinout - not a hard change).
I coulda swore the 6JW8/ECF802 was a drop in compatible but looks like it isn't. The pinout is very different at least.
Anyway, as the OP said, they are not too expensive and there is still supply. Not hugely in demand. I just buy them up whenever I come across them (have a few things besides my Sunn amps that use them) - last year I came across a NOS Rogers 5 pack (rebranded RCAs) in a local radio repair shop and snapped it up.