I'm not familiar with the circuitry on that particular amp, but in general, no, the bias wouldn't be affected. You are correct about the impedance changes.
Do you know that pulling half of the power tubes reduces the power output by only about 3dB? That's not a big change. At a show last year, my bass amp fell over and one of the power tubes broke. I pulled its mate and played the show on half power for that night. The next night I added two tubes back in. There was very little difference. The second night, the sound seemed slightly fuller. In other words, a small difference in tone, but no significant difference in volume.