I'm not a real fan of the 5751. Those that I have tried are too microphonic for my tastes. One thing that you might be aware of, is that the 5751 has a lower gain (70-80) compared to the 12AX7 (100). For this reason, I wouldn't recommend using one in the PI location, as the power amp feedback and related circuitry is designed around the higher gain. I would swap it with the second stage where the circuit gain is less critical.
There are factors too numerous to come up with a complete list, that will affect how the amp sounds... and combine that with how you perceive the sound. Things like choice of speakers, location of the speakers relative to the ear, placement in the room, the room itself and even the number of "bodies" in the room can change the sound... e.g. more bodies absorb more highs.
Personal preference and your mood can change how you perceive the sound... very subjective here. Heck, my Model T sounds best to me when I'm frustrated and working out some anger!!