Not clear at all. Whether or not it will have the frequency response you want depends entirely on what frequency response you want. If you want what it produces, you're good. If not, then not. Likewise, what do you mean by "not musical"?
The 2220 was not designed as a subwoofer. It was designed as a woofer. Do you know the difference? Woofers are used to produce bass, up to the crossover with the midrange (in a three-way system) or the tweeter (in a two-way). Subwoofers are used to fill in the low bass below the woofer. All are "musical" in their way.
The D140, perhaps the most famous musical instrument driver ever, has a high frequency rolloff at about 2000 Hz. That's not very high, but they are very musical. I love mine, but I am considering adding a "tweeter". Midrange, actually. Anyway, the 2220 is probably comparable.