Tim, when I work on an amp and find that some new 'thing' has popped up, I assume that the new noise is related to the work I did. ...a new component is bad, my solder work was sub-par, reversed the leads on a cap. There are a lot of possibilities since I am human and do err. In short, I go back over my work. IF I don't find the problem that way, I start checking voltages. I check to see if tubes are seated in clean sockets. I check tubes.
At some point when the simple approaches don't locate the problem, a signal generator and a scope will track down the problem.
Take care and good luck...