Sure. I have two 200Ss and a Sorado. They're great for guitar IMO, they'll do AC/DC crunch all day long.
By contrast, I also have a Fender Bandmaster. The Bandmaster is brighter and more scooped in the mids, and also stays clean longer; the Sunns crunch up pretty quick.
The only real drawback to Sunns are the cost of tubes; even modern production 6550s are at least twice the price of decent EL34s/6L6s, and 6AN8As aren't ever going to get cheaper.